You just asked a mouthful. I can see why many haven't placed their chips on the table with this.
People aren't very likely to come upon the realization of themselves. They'll likely never fully attain a state of wisdom about their existence. To truly appreciate one thing in life you have to appreciate everything that culminates to create that one thing.
Here's a few things I take to heart:
Everything from the most painful suffering to the most heightened contentment are required to truly appreciate the perception of your world. And these observations ultimately lead to the realization that you can live without them and still maintain your harmony (loose term...couldn't think of a better word, so forgive the hippy jargon).
Conceiving endless possibilities are best applied to strengthen your appreciation of the living universe, and shouldn't leave you feeling caged. Though you may exist in a fragile shell on a small portion of a small rock floating in an infinitely vast universe, you are bigger than you could possibly imagine.
Fascination is the key to appreciation. Once you've appreciated the finite, you'll enter the infinite. There's endless beauty in the simplicity of a rock if you're willing to look for it.
Take comfort in the fact that one day your existence will cease as will all other things.
By existing you are subject to the alteration of the universe around you. Embrace the responsibilities that come from all actions you take and you'll know true comfort.
Through your existence you have the ability to awaken knowledge. Knowledge is the most basic form of consciousness and it will exist so long as the universe exists, even when your universe is terminated.
It comes across as a bit of a guide book, but I take things more as observations, or conceptual breedings. Being able to live through the perspective of your own universe is likely the summary of what I'd like to say. What is, is, and you shouldn't cry for it, or be elated in it, regardless of what it is. Take it as it is and you'll find your peace there within.
Analog's underwear are digital. right now they're set to inverse 1 (I think that means they're on my head).